Foscan® uptake and tissue distribution in relation to photodynamic efficacy
Author Information
Author(s): Cramers P, Ruevekamp M, Oppelaar H, Dalesio O, Baas P, Stewart F A
Primary Institution: The Netherlands Cancer Institute/Antoni van Leeuwenhoek Ziekenhuis
Hypothesis
We hypothesise that it is exposure of the endothelial cells of vessels feeding the tumour to the sensitiser that determines tumour response.
Conclusion
The study suggests that the tumoricidal effect of Foscan-mediated PDT is largely mediated via vascular damage rather than differential tumour drug uptake.
Supporting Evidence
- Foscan levels increase in tumors from 1 to 3 days after injection.
- Clinical data showed drug concentrations in tumors were 5–14 times that in surrounding normal tissue at 2–3 days after administration.
- Illumination at 1, 3, and 6 hours after a single Foscan dose was significantly more effective than longer intervals.
Takeaway
This study looks at how a drug called Foscan works in treating tumors with light. It found that the timing of when the drug is given and when the light is used is really important for it to work well.
Methodology
The study used female nude BalbC mice with implanted human mesothelioma tumors to assess Foscan distribution and PDT response at various time intervals after drug administration.
Limitations
The study was conducted in mice, which may not fully replicate human responses to Foscan and PDT.
Participant Demographics
Female nude BalbC mice, weighing 21–30 g, aged 12–26 weeks.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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