Age-Related Differences in Ketone Metabolism
Author Information
Author(s): Hernandez Ester, Jordan Aydan, Senadheera Chatura, Stephens Elizabeth, Newman John, Kackley Madison, Volek Jeff, Stubbs Brianna
Primary Institution: Buck Institute for Research on Aging
Hypothesis
How does aging influence blood ketone responses to ketone ester consumption?
Conclusion
The study suggests that while there is no overall difference in peak ketone levels across age groups, older adults may have a different metabolic response to ketone esters.
Supporting Evidence
- The highest peak BHB concentration was found in the 41-50 year age group.
- There was a notable difference in BHB AUC between the 21-30 year and 61-70 year age groups.
- Linear regression showed a positive relationship between BHB AUC and age.
Takeaway
This study looked at how older and younger people respond to a type of supplement called ketone esters, finding that older people might process it differently.
Methodology
Open-label, single-arm, observational study where participants consumed ketone esters and had blood samples taken to measure ketone levels.
Limitations
The study had a relatively small sample size and was observational in nature.
Participant Demographics
82 adults aged 20-70 years, with 37 males.
Statistical Information
P-Value
p=0.03
Statistical Significance
p=0.03
Digital Object Identifier (DOI)
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