Cinnamon Extract Reduces Blood Sugar Spikes in Diabetic Rats
Author Information
Author(s): Mohamed Sham Shihabudeen, Hansi Priscilla D, Thirumurugan Kavitha
Primary Institution: VIT University, Vellore, India
Hypothesis
Can cinnamon extract inhibit α-glucosidase activity and control postprandial blood glucose levels in diabetic rats?
Conclusion
Cinnamon bark extract effectively inhibits α-glucosidase, leading to reduced postprandial hyperglycemia in diabetic rats.
Supporting Evidence
- Cinnamon extract showed a dose-dependent inhibition of α-glucosidase activity.
- The IC50 value for yeast α-glucosidase was 5.83 μg/ml.
- Cinnamon extract reduced postprandial blood glucose levels by 78.2% in diabetic rats after maltose loading.
- The inhibition of α-glucosidase by cinnamon extract was found to be competitive and reversible.
Takeaway
Cinnamon can help lower blood sugar levels after eating by slowing down how quickly sugar is absorbed in the body.
Methodology
The study involved in vitro and in vivo experiments using cinnamon extract on diabetic rats to measure its effect on blood glucose levels after carbohydrate loading.
Limitations
The study primarily focused on animal models, and the effects in humans remain to be established.
Participant Demographics
Adult male Albino Wistar rats, aged 12-13 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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