Using Urine S100B Levels to Predict Neonatal Death in Asphyxiated Newborns
Author Information
Author(s): Gazzolo Diego, Frigiola Alessandro, Bashir Moataza, Iskander Iman, Mufeed Hala, Aboulgar Hanna, Venturini Pierluigi, Marras Mauro, Serra Giovanni, Frulio Rosanna, Michetti Fabrizio, Petraglia Felice, Abella Raul, Florio Pasquale
Primary Institution: G. Gaslini Children's Hospital University of Genoa
Hypothesis
Can urine S100B measurement identify full-term infants affected by perinatal asphyxia who are at risk of early postnatal death?
Conclusion
Higher levels of S100B protein in urine suggest a greater risk of neonatal death in asphyxiated newborns.
Supporting Evidence
- S100B levels were significantly higher in newborns who died within the first week compared to healthy controls.
- The study found a 100% sensitivity and specificity for predicting neonatal death at a S100B cut-off of >1.0 µg/L.
- Multiple logistic regression analysis showed a significant correlation between S100B concentrations and neonatal death.
Takeaway
Doctors can check a special protein in the urine of newborns to see if they might be in danger of dying soon after birth.
Methodology
A cross-sectional study measuring S100B protein in urine from 132 term infants, with outcomes assessed at 7 days.
Limitations
The sample size was relatively small, which may limit the generalizability of the findings.
Participant Demographics
Term newborns (37-42 weeks gestation), including 72 healthy infants and 60 with perinatal asphyxia.
Statistical Information
P-Value
p<0.001
Confidence Interval
CI5–95%: 73.4–100
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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