Small Primary Adenocarcinoma in Adenomyosis with Nodal Metastasis: A Case Report
Author Information
Author(s): Puppa Giacomo, Shozu Makio, Perin Tiziana, Nomura Kazuhito, Gloghini Annunziata, Campagnutta Elio, Canzonieri Vincenzo
Primary Institution: Centro di Riferimento Oncologico, Istituto Nazionale Tumori – IRCCS
Hypothesis
The neoplastic transformation of adenomyosis implies an early carcinogenic event involving p53 and COX-2.
Conclusion
Adenocarcinoma in adenomyosis may be affected by local hormonal influence and, despite its small size, may metastasize.
Supporting Evidence
- The patient had a moderately differentiated adenocarcinoma measuring 0.8 cm.
- Immunohistochemical studies showed strong positivity for estrogen receptors and COX-2.
- The carcinoma was diagnosed after the patient underwent total hysterectomy.
Takeaway
A small tumor in a woman's uterus turned into cancer and spread to her lymph nodes, showing that even tiny tumors can be dangerous.
Methodology
The tissues were fixed in Bouin solution, embedded in paraffin, and stained for histologic processing and immunohistochemical studies.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
The patient was a 57-year-old nulliparous woman.
Digital Object Identifier (DOI)
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