Embryonic Lethality in Mice Lacking the Nuclear Factor of Activated T Cells 5 Protein Due to Impaired Cardiac Development and Function
2011
Embryonic Lethality in Mice Lacking NFAT5 Protein
publication
Evidence: high
Author Information
Author(s): Mak Man Chi, Lam Ka Man, Chan Ping Kei, Lau Yu Bond, Tang Wai Ho, Yeung Patrick Ka Kit, Ko Ben Chi Bun, Chung Stephen Man Sum, Chung Sookja Kim
Primary Institution: The University of Hong Kong
Hypothesis
The study investigates the role of NFAT5 in cardiac development and its impact on embryonic lethality in mice.
Conclusion
NFAT5 is essential for normal cardiac development, and its absence leads to embryonic lethality due to impaired heart function.
Supporting Evidence
- NFAT5−/− embryos showed peripheral edema and abnormal heart development.
- Cardiomyocytes from NFAT5−/− embryos had a significantly reduced beating rate.
- Expression of NFAT5 target genes was reduced in NFAT5−/− cardiomyocytes.
Takeaway
Mice without a protein called NFAT5 can't develop their hearts properly, which causes them to die before they are born.
Methodology
The study involved creating NFAT5 gene knockout mice and analyzing their cardiac development and function.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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