2′-Carboxymethoxy-4,4′-bis(3-methylbut-2-enyloxy)chalcone
2011
Crystal Structure of Sofalcione
publication
Evidence: high
Author Information
Author(s): Liang Yan-Shu, Mu Shuai, Wang Jing-Yang, Liu Deng-Ke
Primary Institution: Tianjin University of Commerce
Hypothesis
What is the crystal structure of the anti-ulcer agent sofalcone?
Conclusion
The study presents the crystal structure of sofalcone, revealing its molecular arrangement and interactions.
Supporting Evidence
- The two benzene rings in sofalcone form a dihedral angle of 6.78°.
- Intermolecular hydrogen bonds link the molecules into centrosymmetric dimers.
- π–π interactions between the benzene rings stabilize the crystal packing.
Takeaway
This study shows how the molecules of sofalcone are arranged in a crystal, which helps us understand how it might work as a medicine.
Methodology
The crystal structure was determined using X-ray diffraction techniques.
Limitations
The precise molecular mechanism of sofalcone's action is not fully understood.
Digital Object Identifier (DOI)
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