Expression patterns of protein kinase D 3 during mouse development
2008
Expression patterns of protein kinase D 3 during mouse development
publication
Evidence: moderate
Author Information
Author(s): Ellwanger Kornelia, Pfizenmaier Klaus, Lutz Sylke, Hausser Angelika
Primary Institution: Institute of Cell Biology and Immunology, University of Stuttgart
Hypothesis
The physiological functions of PKD3 during development remain unknown.
Conclusion
The data presented support an important role for PKD3 during development of these tissues.
Supporting Evidence
- PKD3 is differentially expressed during organogenesis.
- Strong PKD3 expression is detected in the developing heart from E10 to E16.5.
- PKD3 expression increases in neuronal and supporting connective tissue from E12.5.
Takeaway
PKD3 is a protein that helps in the development of certain tissues in mice, especially the heart and muscles.
Methodology
The expression pattern of PKD3 was examined during mouse embryonic development using immunohistochemistry.
Limitations
Transgenic mouse models to study PKD3 functions in vivo are not available.
Digital Object Identifier (DOI)
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