The Gut–Heart Axis: Effects of Intestinal Microbiome Modulation on Cardiovascular Disease
Author Information
Author(s): Sagmeister Alexandra, Matter Christian M., Stähli Barbara E., Scharl Michael
Primary Institution: University Hospital Zurich, University of Zurich
Hypothesis
Can intestinal microbiome modulation prevent or treat cardiovascular disease (CVD)?
Conclusion
Modulating the gut microbiome through various interventions can decrease cardiovascular risk markers and factors, but their effects on clinical endpoints need further investigation.
Supporting Evidence
- Beneficial effects were observed upon lifestyle intervention and probiotics use.
- The Mediterranean diet, high-fiber diets, and polyphenol-rich diets showed promise in reducing CVD risk factors.
- Empagliflozin was the only drug intervention that demonstrated beneficial effects on CVD risk factors.
Takeaway
This study looks at how changing the bacteria in our gut can help keep our hearts healthy. Eating better and taking probiotics can make a difference!
Methodology
A systematic literature review of randomized clinical trials on microbiome modulation and its effects on CVD risk published between August 2018 and August 2023.
Potential Biases
Publication bias may exist as studies with positive outcomes could be published preferentially.
Limitations
The included studies were heterogeneous, had small sample sizes, and short intervention periods, limiting the generalizability of the results.
Participant Demographics
The review included various populations with different health statuses, including those with metabolic syndrome and obesity.
Digital Object Identifier (DOI)
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