Impact of c-JUN deficiency on thalamus development in mice and human neural models
Author Information
Author(s): Shi Jiantao, Chen Qing, Lai Jianheng, Zhu Jieying, Zhang Ran, Mazid Md. Abdul, Li Dongwei
Primary Institution: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Hypothesis
c-JUN plays significant roles in nervous system development.
Conclusion
c-JUN depletion impedes the extension of nerve fibers and renders the thalamus susceptible to dysplasia during early mouse embryonic development and human ThO patterning.
Supporting Evidence
- c-Jun KO mice exhibited malformation of the thalamus and sparse nerve fibers.
- Absence of c-JUN accelerated the induction of neural progenitor cells but impaired fiber extension.
- Overexpression of c-JUN rescued developmental defects in thalamus organoids.
- RNA-seq identified significant changes in gene expression related to thalamus development.
Takeaway
c-JUN is like a helper for brain development; without it, the brain doesn't grow properly, especially in a part called the thalamus.
Methodology
Used c-Jun knockout mice and c-JUN KO embryonic stem cells-derived neural progenitor cells, cerebral organoids, and thalamus organoids models to investigate the influence of c-JUN on early nervous system development.
Limitations
The study primarily focuses on the role of c-JUN in specific models and may not fully represent all aspects of neural development.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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