Study of Biofilm-Forming Prevotella intermedia Strain 17
Author Information
Author(s): Yamanaka Takeshi, Furukawa Tomoyo, Matsumoto-Mashimo Chiho, Yamane Kazuyoshi, Sugimori Chieko, Nambu Takayuki, Mori Naoki, Nishikawa Hiroyuki, Walker Clay B, Leung Kai-Poon, Fukushima Hisanori
Primary Institution: Osaka Dental University
Hypothesis
The ability of P. intermedia strain 17 to produce viscous materials might be essential for its biofilm formation.
Conclusion
The capacity to form biofilm in P. intermedia contributes to their resistance against host innate defense responses.
Supporting Evidence
- Strain 17 induced greater abscess formation in mice compared to strain 17-2.
- Strain 17 showed an ability to interfere with the phagocytic activity of human neutrophils.
- Gene expression analysis revealed significant up-regulation of heat shock proteins in strain 17.
Takeaway
This study found that a type of bacteria called Prevotella intermedia can create a protective layer that helps it survive attacks from the body's immune system.
Methodology
The study compared two strains of P. intermedia in terms of biofilm formation and pathogenicity using microarray assays and animal models.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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