Infectious clones of Tomato leaf curl Palampur virus with a defective DNA B and their pseudo-recombination with Tomato leaf curl New Delhi virus
2011

Infectious Clones of Tomato Leaf Curl Palampur Virus and Their Interaction with Other Viruses

Sample size: 60 publication Evidence: moderate

Author Information

Author(s): Malik Aamir Humayun, Briddon Rob W, Mansoor Shahid

Primary Institution: Agricultural Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan

Hypothesis

Can Tomato leaf curl Palampur virus (ToLCPMV) interact with other viruses to cause disease in muskmelon?

Conclusion

The study found that ToLCPMV is associated with muskmelon leaf curl disease, but its defective nuclear shuttle protein (NSP) may limit its infectivity without the presence of Zucchini yellow mosaic virus (ZYMV).

Supporting Evidence

  • ToLCPMV was found to have the highest DNA sequence identity with other isolates.
  • Inoculation with ToLCPMV DNA A and ToLCNDV DNA B resulted in typical disease symptoms.
  • The NSP gene of ToLCPMV was found to be truncated, affecting its infectivity.

Takeaway

Researchers studied a virus that affects melons and found it needs help from another virus to make the plants sick.

Methodology

Samples were collected from symptomatic plants, and DNA was extracted and analyzed using PCR and sequencing.

Limitations

The study did not confirm the infectivity of ToLCPMV clones in natural hosts without the presence of ZYMV.

Digital Object Identifier (DOI)

10.1186/1743-422X-8-173

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