Effectiveness of Non-Adjuvanted Pandemic Influenza A Vaccines for Preventing Pandemic Influenza Acute Respiratory Illness Visits in 4 U.S. Communities

2011

Effectiveness of Pandemic Influenza A Vaccines

Sample size: 6757 publication 10 minutes Evidence: moderate

Author Information

Author(s): Griffin Marie R., Monto Arnold S., Belongia Edward A., Treanor John J., Chen Qingxia, Chen Jufu, Talbot H. Keipp, Ohmit Suzanne E., Coleman Laura A., Lofthus Gerry, Petrie Joshua G., Meece Jennifer K., Hall Caroline Breese, Williams John V., Gargiullo Paul, Berman LaShondra, Shay David K.

Primary Institution: Vanderbilt University Medical Center

Hypothesis

What is the effectiveness of non-adjuvanted pandemic influenza A vaccines in preventing acute respiratory illness visits?

Conclusion

Non-adjuvanted pandemic influenza vaccines provided significant protection against medically attended influenza illnesses.

Supporting Evidence

1,011 patients tested positive for pandemic influenza virus.
Adjusted effectiveness for pandemic vaccines combined was 56%.
Effectiveness for inactivated vaccines alone was 62% overall.
Live attenuated vaccine showed effectiveness only if vaccination was more than 7 days prior to illness onset.

Takeaway

The study found that getting a pandemic flu vaccine helped people avoid going to the doctor for flu-related sickness.

Methodology

Patients with acute respiratory illness were enrolled and tested for influenza, with vaccine effectiveness estimated using logistic regression models.