Cinnarizine and flunarizine as radiation sensitisers in two murine tumours
1988
Cinnarizine and Flunarizine as Radiation Sensitizers in Murine Tumors
Sample size: 8
publication
Evidence: moderate
Author Information
Author(s): P.J. Wood, D.G. Hirst
Primary Institution: Stanford University School of Medicine
Hypothesis
The study investigates the effect of calcium antagonists cinnarizine and flunarizine on the radiation sensitivity of two murine tumors.
Conclusion
Flunarizine may have potential use as a radiosensitizer, particularly in the SCCVII/St tumor.
Supporting Evidence
- Flunarizine produced a significant increase in cell killing in the SCCVII/St tumor.
- Cinnarizine had no significant effect on cell survival in the RIF-1 tumor.
- Flunarizine was more effective than cinnarizine at the tested doses.
Takeaway
Flunarizine helps make certain tumors more sensitive to radiation, which could improve cancer treatment.
Methodology
Mice were treated with cinnarizine or flunarizine before exposure to X-rays, and tumor responses were measured.
Limitations
The study primarily focused on two tumor types and may not generalize to all tumors.
Participant Demographics
C3H/Km female mice, 12-14 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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