Radiation induced CNS toxicity – molecular and cellular mechanisms
2001
Understanding Radiation Induced CNS Toxicity
publication
Author Information
Author(s): Belka C, Budach W, Kortmann R D, Bamberg M
Primary Institution: Department of Radiation Oncology, University of Tübingen
Hypothesis
What are the molecular and cellular mechanisms behind radiation induced CNS toxicity?
Conclusion
Radiation can cause various types of damage in the CNS, including demyelination and loss of specific cell types.
Supporting Evidence
- Radiotherapy of tumors near the CNS is limited by the sensitivity of normal tissue.
- A detailed understanding of radiation induced CNS toxicity mechanisms is necessary for developing treatment protocols.
- Several types of lesions can occur due to radiation, including demyelination and endothelial cell loss.
Takeaway
When radiation is used to treat tumors near the brain, it can hurt healthy brain cells in different ways.
Methodology
The article reviews existing data on the cellular and molecular basis of radiation induced CNS side effects.
Digital Object Identifier (DOI)
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