Bayesian Analysis of Hypertension Linkage in Framingham Study
Author Information
Author(s): Logue Mark W, Goedken Rhinda J, Vieland Veronica J
Primary Institution: University of Iowa
Hypothesis
Is there evidence of linkage for hypertension in the Framingham Heart Study data?
Conclusion
The study found little evidence for a hypertension-predisposing gene across the chromosomes examined.
Supporting Evidence
- 73% of the posterior probabilities of linkage were below the prior probability of linkage.
- The maximum posterior probability of linkage was 4.5% on chromosome 1.
- The study suggests that the PPL analysis remains inconclusive.
Takeaway
The researchers looked for genes that might cause high blood pressure but didn't find strong evidence for any.
Methodology
The study used a model-integrated multipoint Bayesian analysis to compute posterior probabilities of linkage for several chromosomes.
Potential Biases
Potential low power and misleading results due to pedigree trimming and splitting.
Limitations
The analysis may lack sufficient data and the phenotype definition may not be genetically relevant.
Participant Demographics
The dataset included 3695 individuals, with 1312 coded as affected, 232 as unaffected, and 2151 as unknown.
Digital Object Identifier (DOI)
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