Methylene Blue for Ifosfamide-Induced Encephalopathy
Author Information
Author(s): Pelgrims J, Vos F De, Brande J Van den, Schrijvers D, Prové A, Vermorken J B
Primary Institution: Department of Medical Oncology, University Hospital Antwerp
Hypothesis
Does methylene blue have a neuroprotective effect in patients treated with ifosfamide who develop encephalopathy?
Conclusion
Methylene blue is an effective treatment for ifosfamide-induced encephalopathy and may also be used as a prophylactic agent.
Supporting Evidence
- Ten to 15% of patients treated with ifosfamide develop encephalopathy.
- Twelve patients developed CNS depression, with eight treated with methylene blue.
- Four patients treated with methylene blue recovered fully within 24 hours.
Takeaway
Methylene blue can help patients who get sick in the brain from a medicine called ifosfamide, and it might even help prevent this sickness.
Methodology
The study evaluated 12 patients who developed CNS depression after ifosfamide treatment and assessed the effects of methylene blue on their recovery.
Participant Demographics
Patients aged 16 to 77 years with solid tumors.
Digital Object Identifier (DOI)
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