Pain Relief and Inflammation Reduction from Pogostemon cablin Extract
Author Information
Author(s): Lu Tsung-Chun, Liao Jung-Chun, Huang Tai-Hung, Lin Ying-Chih, Liu Chia-Yu, Chiu Yung-jia, Peng Wen-Huang
Primary Institution: China Medical University
Hypothesis
The study aims to investigate the analgesic and anti-inflammatory properties of Pogostemon cablin methanol extract in vivo.
Conclusion
The study demonstrated that Pogostemon cablin methanol extract has significant analgesic and anti-inflammatory effects.
Supporting Evidence
- PCMeOH significantly decreased the acetic acid-induced writhing responses.
- PCMeOH reduced licking time in the second phase of the formalin test.
- Carr-induced paw edema inflammation was significantly reduced in a dose-dependent manner with PCMeOH.
- PCMeOH increased the activities of antioxidant enzymes in the liver.
- PCMeOH decreased levels of malondialdehyde in the edema paw.
Takeaway
This study found that a herbal extract from Pogostemon cablin can help reduce pain and swelling in mice.
Methodology
The study used acetic acid-induced writhing response and formalin test for analgesic activity, and Carr-induced paw edema model for anti-inflammatory activity in mice.
Participant Demographics
ICR mice, 18-22g
Statistical Information
P-Value
p<0.05–.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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