Cellular accumulation of the anticancer agent cisplatin: A review
1993
Cisplatin Accumulation in Cancer Cells
publication
Evidence: moderate
Author Information
Author(s): D.P. Gately, S.B. Howell
Primary Institution: University of California, San Diego
Hypothesis
The mechanism of cisplatin accumulation in resistant cancer cells is not fully understood.
Conclusion
Cisplatin enters cells through a process that is modulated by various agents, despite not being saturable.
Supporting Evidence
- Decreased accumulation of cisplatin is a common feature in resistant cancer cells.
- Various pharmacological agents can modulate cisplatin accumulation.
- Temperature and extracellular conditions affect the uptake of cisplatin.
Takeaway
Cisplatin is a cancer drug that can get into cells, but some cancer cells learn to keep it out, making the drug less effective.
Methodology
The review summarizes existing data on cisplatin accumulation mechanisms and discusses various studies on drug uptake.
Limitations
The review does not provide new experimental data but synthesizes existing literature.
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