Tumorigenicity of Psoriasis Therapies
Author Information
Author(s): D.H. Phillips, A.J. Alldrick
Primary Institution: Haddow Laboratories, Institute of Cancer Research
Hypothesis
Does the combination of coal tar and dithranol increase tumorigenicity in mice compared to using either agent alone?
Conclusion
The combination of coal tar and dithranol in treatment led to the development of skin papillomas in mice, while neither agent alone did.
Supporting Evidence
- Coal tar and dithranol together caused tumors in 15% of treated mice.
- None of the mice treated with coal tar or dithranol alone developed tumors.
- Previous studies indicated the carcinogenicity of coal tar in mice.
Takeaway
When mice were treated with both coal tar and dithranol, they developed skin tumors, but those treated with just one of the treatments did not.
Methodology
Female CD-1 mice were treated with coal tar followed by dithranol, and tumor development was monitored.
Limitations
The study was conducted on mice, which may not fully represent human responses.
Participant Demographics
Female CD-1 mice, aged 7-8 weeks.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
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