Metabolic Complete Response of Metastatic Oncogene-Negative, PDL1-Negative Non-Small Cell Lung Cancer After Chemo-Immunotherapy and Radiotherapy: A Case Report
2024

Complete Response in Lung Cancer After Treatment

Sample size: 1 publication Evidence: low

Author Information

Author(s): Surgo Alessia, Davì Valerio, Ciliberti Maria Paola, Carbonara Roberta, Caliandro Morena, Di Guglielmo Fiorella Cristina, Sasso Nicola, Calbi Roberto, Gentile Maria Annunziata, Talienti Tiziana, Bruno Isabella, Troia Michele, Bonaparte Ilaria, Ludovico Giuseppe Mario, Surico Giammarco, Fiorentino Alba

Primary Institution: General Regional Hospital F. Miulli

Hypothesis

Can a combination of chemotherapy, immunotherapy, and radiotherapy lead to a complete metabolic response in a patient with metastatic non-small cell lung cancer?

Conclusion

The patient achieved a complete metabolic response and remains alive 37 months after diagnosis.

Supporting Evidence

  • The patient had a complete clinical response to therapy after 37 months.
  • Initial cancer markers showed significant improvement after treatment.
  • Imaging confirmed a reduction in tumor size and no new lesions.

Takeaway

A 71-year-old man with advanced lung cancer got better after receiving a mix of treatments, showing that even tough cases can improve.

Methodology

The patient underwent stereotactic radiotherapy, chemotherapy with cisplatin and pemetrexed, and immunotherapy with Atezolizumab.

Limitations

The study is based on a single case report, limiting generalizability.

Participant Demographics

71-year-old male ex-smoker with a history of hypertension and bladder cancer.

Digital Object Identifier (DOI)

10.3390/curroncol31120598

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