Sodium Phenylbutyrate Protects Kidneys from Cisplatin Damage
Author Information
Author(s): Oh Chang Joo, Choi Wooyoung, Lee Ha Young, Lee In-Kyu, Kim Min-Ji, Jeon Jae-Han, Maringhini Silvio
Primary Institution: Kyungpook National University
Hypothesis
Can sodium phenylbutyrate prevent cisplatin-induced acute kidney injury?
Conclusion
Sodium phenylbutyrate effectively prevents cisplatin-induced acute kidney injury by suppressing the expression of pyruvate dehydrogenase kinase 4.
Supporting Evidence
- 4-PBA treatment reduced tubular injury scores in mice.
- Serum levels of blood urea nitrogen and creatinine were normalized with 4-PBA treatment.
- Inflammatory markers TNF-α and ICAM-1 were suppressed by 4-PBA.
- 4-PBA reduced apoptosis in renal tubular cells.
- 4-PBA restored mitochondrial function in cisplatin-treated cells.
Takeaway
This study shows that a drug called sodium phenylbutyrate can help protect kidneys from damage caused by another drug called cisplatin.
Methodology
Mice were treated with sodium phenylbutyrate and cisplatin, followed by assessments of kidney injury, inflammation, and mitochondrial function.
Limitations
The exact molecular mechanisms by which sodium phenylbutyrate reduces Pdk4 expression were not fully elucidated.
Participant Demographics
Seven-week-old male C57BL6J mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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