Prognostic Factors and Treatment for Bone Lymphoma
Author Information
Author(s): A.J. Rathmell, M.K. Gospodarowicz, S.B. Sutcliffe, R.M. Clark
Primary Institution: The Princess Margaret Hospital
Hypothesis
What are the prognostic factors and optimal treatment strategies for localized lymphoma of bone?
Conclusion
Patients with localized lymphoma of bone treated with chemotherapy and radiation therapy have significantly better survival rates compared to those treated with radiation therapy alone.
Supporting Evidence
- Survival was significantly better for patients treated by chemotherapy plus radiation therapy (88% at 5 years) compared to radiation therapy alone (40% at 5 years).
- Patients aged less than 60 years had a 5-year survival rate of 72%, while those over 60 had a rate of 30%.
- The relapse-free rate was 89% at 5 years for patients treated with chemotherapy plus radiation therapy compared to 27% for those treated with radiation therapy alone.
Takeaway
This study looked at patients with lymphoma in their bones and found that those who got both chemotherapy and radiation did much better than those who only got radiation.
Methodology
The study reviewed records of adult patients with malignant lymphoma involving bone from 1967 to 1988, focusing on treatment outcomes and prognostic factors.
Limitations
The study included a small number of patients and did not assess the impact of histological subtype on survival due to insufficient numbers.
Participant Demographics
Median age was 53 years, with 14 males and 13 females; age ranged from 20 to 88 years.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
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