Anti-Inflammatory Effects of Eupatorium adenophorum Leaf Extract
Author Information
Author(s): Ashim K. Chakravarty, Tamal Mazumder, Shankar N. Chatterjee
Primary Institution: University of North Bengal
Hypothesis
Can the ethanolic leaf extract of Eupatorium adenophorum Spreng. serve as a novel anti-inflammatory agent?
Conclusion
The ethanolic leaf extract of Eupatorium adenophorum effectively inhibits inflammation and promotes tissue repair.
Supporting Evidence
- EEA treatment significantly increased the number of CD4+ T cells in DTH mice.
- EEA inhibited the swelling caused by DTH reaction by up to 60%.
- EEA increased serum TNF-α levels in treated mice compared to controls.
- EEA effectively scavenged hydroxyl radicals, reducing oxidative stress.
- EEA downregulated the expression of pro-inflammatory cytokine IL-1β.
Takeaway
This study shows that a plant extract can help reduce swelling and inflammation in mice, which might help in healing injuries.
Methodology
The study used Swiss Albino mice to test the effects of the ethanolic leaf extract on delayed type hypersensitivity reactions induced by dinitrofluorobenzene.
Limitations
The active compound in the extract has not been identified, and the study was conducted only in mice.
Participant Demographics
Inbred adult Swiss Albino mice of both sexes, aged 12–16 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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