Prognostic Nutritional Index and Liver Cancer Survival
Author Information
Author(s): Zhang Haiyan, Li Dan, Li Jing
Primary Institution: Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Hypothesis
What is the relationship between preoperative prognostic nutritional index (PNI) and cancer survival in patients with hepatocellular carcinoma (HCC)?
Conclusion
Higher preoperative PNI is associated with improved survival outcomes in HCC patients undergoing curative hepatectomy.
Supporting Evidence
- Higher PNI was significantly associated with longer overall survival (OS) and recurrence-free survival (RFS).
- Significant heterogeneity was found among studies for RFS.
- Subgroup analysis indicated that age and PNI cutoff values contributed to heterogeneity.
Takeaway
If you have liver cancer and your nutritional score is high before surgery, you're likely to live longer after the operation.
Methodology
A systematic review and meta-analysis of 19 studies evaluating the prognostic value of PNI in HCC patients after surgery.
Potential Biases
Two studies exhibited a moderate risk of bias; the rest had a low risk.
Limitations
All included studies were retrospective, and the cut-off values for PNI varied across studies.
Participant Demographics
The studies included a total of 9,830 patients, predominantly male, with ages ranging from 49.6 to 70.5 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 1.44–1.77
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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