Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis

2008

Genetic Factors in Knee Osteoarthritis in East Asian Populations

Sample size: 1705 publication Evidence: moderate

Author Information

Author(s): Shi Dongquan, Nakamura Takahiro, Nakajima Masahiro, Dai Jin, Qin Jianghui, Ni Haijian, Xu Yong, Yao Chen, Wei Jia, Liu Baorui, Ikegawa Shiro, Jiang Qing

Primary Institution: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University

Hypothesis

Are single nucleotide polymorphisms in RHOB and TXNDC3 associated with knee osteoarthritis susceptibility in East Asian populations?

Conclusion

The study found a significant association of TXNDC3 with knee osteoarthritis susceptibility in East Asian populations, but not for RHOB.

Supporting Evidence

A significant association of RHOB with knee OA was observed in male Chinese patients.
The association of TXNDC3 was replicated in Chinese female and Japanese patients.
No significant association was found in the meta-analysis for all studies.

Takeaway

This study looked at genes that might make people more likely to get knee arthritis and found one gene linked to it in East Asians.

Methodology

Two case-control studies were conducted with genotyping of SNPs in patients with knee osteoarthritis and matched controls, followed by a meta-analysis.