Mammographic Density and Ki-67 Expression in High-Risk Women
Author Information
Author(s): Qamar J. Khan, Bruce F. Kimler, Anne P. O'Dea, Carola M. Zalles, Priyanka Sharma, Carol J. Fabian
Primary Institution: University of Kansas Medical Center
Hypothesis
Is there a correlation between mammographic density and Ki-67 expression in benign breast cells obtained by random periareolar fine needle aspiration?
Conclusion
Mammographic density and Ki-67 expression do not correlate, suggesting they may serve as complementary biomarkers in breast cancer chemoprevention trials.
Supporting Evidence
- Ki-67 expression increased with cytologic abnormality and younger age.
- Mammographic density was higher in premenopausal women and those with lower body mass index.
- No correlation was found between mammographic density and Ki-67 expression.
Takeaway
This study looked at women at high risk for breast cancer and found that the density of their breast tissue on mammograms didn't relate to a specific cancer marker called Ki-67.
Methodology
The study involved 344 high-risk women who underwent random periareolar fine needle aspiration, with assessments of cytomorphology and Ki-67 expression, alongside mammographic density measurements.
Potential Biases
Potential bias may arise from the selection of participants and the reliance on self-reported risk factors.
Limitations
The study may be limited by the specific population of high-risk women and the potential confounding effects of hormone replacement therapy.
Participant Demographics
The median age of participants was 48 years, with 47% premenopausal and 53% postmenopausal.
Statistical Information
P-Value
p ≤ 0.001
Statistical Significance
p ≤ 0.001
Digital Object Identifier (DOI)
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