Interleukin-2 receptor chain as a possible target for low doses of mafosfamide
1995
Mafosfamide's Effect on IL-2 Receptor in Cytotoxic Lymphocytes
publication
Evidence: moderate
Author Information
Author(s): A. Pukhalsky, A. Toptygina, S. Khaidukov
Primary Institution: Research Centre for Medical Genetics
Hypothesis
Is the p75 chain of the IL-2 receptor a target for low doses of mafosfamide?
Conclusion
Mafosfamide inhibits the proliferative response of cytotoxic lymphocytes by blocking the IL-2 receptor's p75 chain.
Supporting Evidence
- Mafosfamide strongly suppressed the response of 7-day CTL to IL-2.
- CsA did not suppress IL-2 stimulated CTL but inhibited Con A-stimulated spleen cell proliferation.
- Blocking the suppressor cell activity restored the normal lymphocyte response level.
Takeaway
Mafosfamide can stop certain immune cells from growing by blocking a specific part of their receptor.
Methodology
Mice were treated with mafosfamide and their lymphoid cells were analyzed for IL-2 receptor expression and proliferation response.
Participant Demographics
Male mice weighing 22-24 g from various strains.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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