IMPROVING GLUTATHIONE, MITOCHONDRIA, INFLAMMATION, AND COGNITIVE DECLINE: A PILOT CLINICAL TRIAL OF GLYNAC IN AGING
2024
Improving Cognitive Function in Aging with GlyNAC
publication
Evidence: moderate
Author Information
Author(s): Sekhar Rajagopal, Kumar Premranjan, Liu Chun, Hsu Jean, Shaji Chacko, Farook Jahoor, Charles Minard
Primary Institution: Baylor College of Medicine
Hypothesis
Can GlyNAC supplementation improve cognitive decline and related physiological defects in older adults?
Conclusion
GlyNAC supplementation for 24 weeks reversed cognitive decline and related physiological defects in older adults.
Supporting Evidence
- Older adults showed cognitive decline and several physiological defects compared to young adults.
- GlyNAC supplementation improved glutathione levels and cognitive function.
- Stopping GlyNAC led to a return of cognitive decline and physiological defects.
- A novel 'brain glucose steal' phenomenon was identified, where non-brain organs used glucose meant for the brain.
Takeaway
Older people often have trouble thinking clearly, but taking GlyNAC can help their brains work better.
Methodology
A 36-week pilot clinical trial comparing young and older adults, assessing the effects of GlyNAC supplementation.
Participant Demographics
Older adults and young adults were compared in the study.
Digital Object Identifier (DOI)
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