Factors that can affect the external validity of randomised controlled trials
2006
Factors Affecting the Validity of Randomised Controlled Trials
publication
Evidence: moderate
Author Information
Author(s): Peter M. Rothwell
Primary Institution: University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, United Kingdom
Hypothesis
What factors influence the external validity of randomised controlled trials?
Conclusion
Many randomised controlled trials lack external validity, which limits their applicability in routine clinical practice.
Supporting Evidence
- Many trials are criticized for their lack of external validity.
- External validity is essential for the correct application of treatments in clinical practice.
- Selection criteria in trials often exclude many patients who would benefit from treatment.
Takeaway
This study talks about how some medical trials don't always apply to all patients, making it hard for doctors to use their results in real life.
Potential Biases
Potential bias due to selective reporting and exclusion criteria in trials.
Limitations
The review does not exhaustively cover all determinants of external validity.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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