Wound healing potential of mouth gel containing isopimarane diterpene from Kaempferia galanga rhizomes for treatment of oral stomatitis
2024
Wound Healing Potential of Mouth Gel from Kaempferia galanga
publication
10 minutes
Evidence: high
Author Information
Author(s): Iadnut Anupon, Sae-lee Tanawan, Tewtrakul Supinya, Iriti Marcello
Primary Institution: Prince of Songkla University
Hypothesis
This study aims to evaluate the wound healing potential of KG6, a compound isolated from Kaempferia galanga, by examining its biological activities.
Conclusion
The study confirms that the 0.50% KG6 mouth gel has significant wound healing properties for treating oral ulcers.
Supporting Evidence
- KG6 mouth gels showed good stability in physical and chemical properties.
- The 0.50% KG6 mouth gel significantly inhibited nitric oxide production.
- KG6 enhanced cell proliferation and migration in human gingival fibroblasts.
- KG6 mouth gels exhibited antioxidant activity against H2O2-induced oxidative stress.
Takeaway
This study shows that a gel made from a plant called Kaempferia galanga can help heal mouth sores.
Methodology
The study formulated mouth gels with different concentrations of KG6 and tested their stability, anti-inflammatory effects, cell proliferation, migration, and antioxidant activity.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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