Combining Tigecycline and Apramycin to Fight Antibiotic Resistance
Author Information
Author(s): Liu Juan, Zheng Si-Lin, Wu Jing-Jing, Zheng Mei, Cai Da-Tong, Zhang Yan, Sun Jian, Liao Xiao-Ping, Yu Yang
Primary Institution: South China Agricultural University
Hypothesis
Can the combination of tigecycline and apramycin effectively overcome tet(X)-mediated resistance in Acinetobacter spp.?
Conclusion
The combination of tigecycline and apramycin shows synergistic activity against tet(X)-harboring Acinetobacter spp., reducing the required dosage of tigecycline.
Supporting Evidence
- The combination therapy significantly reduced bacterial counts in a mouse model.
- FICI values indicated strong synergism between tigecycline and apramycin.
- MICs of tigecycline decreased significantly in the presence of apramycin.
Takeaway
This study found that mixing two antibiotics, tigecycline and apramycin, can help fight off tough bacteria that are resistant to treatment.
Methodology
The study used in vitro chequerboard experiments, time-kill assays, and a mouse model to evaluate the efficacy of the antibiotic combinations.
Limitations
The study primarily focused on in vitro and animal models, which may not fully represent human responses.
Participant Demographics
Nine Acinetobacter isolates were derived from human, pig, migratory bird, and environmental samples.
Statistical Information
P-Value
0.088
Confidence Interval
95%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website