The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins
2007
NCOA7 and Its Role in Oxidation Resistance
publication
Evidence: moderate
Author Information
Author(s): Durand Mathieu, Kolpak Adrianne, Farrell Timothy, Elliott Nathan A, Shao Wenlin, Brown Myles, Volkert Michael R
Primary Institution: University of Massachusetts Medical School
Hypothesis
Does NCOA7 have an oxidation resistance function similar to OXR1?
Conclusion
NCOA7 can reduce DNA damage from reactive oxygen species, indicating it contributes to oxidation resistance.
Supporting Evidence
- NCOA7 can suppress the oxidative mutator phenotype in E. coli.
- NCOA7 is constitutively expressed and not induced by oxidative stress.
- NCOA7 localizes to the nucleus and interacts with the estrogen receptor.
Takeaway
NCOA7 is a protein that helps protect cells from damage caused by harmful molecules called reactive oxygen species, similar to another protein called OXR1.
Methodology
The study involved expressing NCOA7 in E. coli to test its ability to suppress oxidative mutagenesis and analyzing its localization in human cells.
Digital Object Identifier (DOI)
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