Study on Anxiety and Quality of Life in Women with Kidney Disease
Author Information
Author(s): Furtak Gabriela, Lerch Natalia, Kozłowski Mateusz, Tkacz Piotr, Piekara Emilia, Łagódka Maria, Durys Damian, Gutowska Izabela, Widecka Krystyna, Marchelek-Myśliwiec Małgorzata, Żwierełło Wojciech, Cymbaluk-Płoska Aneta, Saitoh Akiyoshi
Primary Institution: Pomeranian Medical University in Szczecin
Hypothesis
Higher anxiety correlates with higher levels of IL-8, RANTES, MIG, MCP-1, IP-10 and IL-12p70.
Conclusion
The study found that higher levels of IL-8 and RANTES are associated with lower quality of life in women with chronic kidney disease or after kidney transplantation.
Supporting Evidence
- Lower quality of life was found in the group with a higher IL-8 concentration.
- A positive weak correlation was found between decreased quality of life and IL-8 and RANTES.
- Higher RANTES levels increase the odds of a lower quality of life.
- 23 out of 107 patients had high total anxiety.
- Significant differences were found in the distributions of IL-8 and RANTES scores.
Takeaway
Women with kidney problems often feel anxious, and this can make their lives feel worse. The study looked at how certain proteins in their blood might be linked to their feelings.
Methodology
The study used STAI and SF-36 questionnaires to assess anxiety and quality of life, along with blood samples to measure protein levels.
Potential Biases
Selection bias may have occurred as participants were informed they were part of a study.
Limitations
The study had a small sample size and did not account for other factors like mental health history or family support.
Participant Demographics
The study included 107 women, primarily those with chronic kidney disease or after kidney transplantation.
Statistical Information
P-Value
p = 0.033 for IL-8, p = 0.028 for RANTES
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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