Link Between Obesity and HDL-C Levels in Framingham Study
Author Information
Author(s): Arya Rector, Lehman Donna, Hunt Kelly J, Schneider Jennifer, Almasy Laura, Blangero John, Stern Michael P, Duggirala Ravindranath
Primary Institution: University of Texas Health Science Center, San Antonio, Texas, USA
Hypothesis
Are there common genetic loci influencing both obesity and HDL-C levels?
Conclusion
The study found strong evidence for a genetic region that influences both BMI and HDL-C levels.
Supporting Evidence
- The study identified a major locus near marker D6S1009 influencing variation in BMI.
- A major locus for HDL-C was found near marker D2S1334 on chromosome 2.
- Bivariate analysis implicated the genetic region near marker D6S1009 as influencing both traits.
Takeaway
Scientists looked at a lot of people's genes to see if the same genes affect weight and good cholesterol levels, and they found some that do.
Methodology
Bivariate multipoint linkage analysis was used to identify genetic loci affecting both BMI and HDL-C.
Participant Demographics
Participants included individuals from the original and offspring cohorts of the Framingham Heart Study.
Statistical Information
P-Value
1.8 × 10-7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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