Cancer Stem Cell Radioresistance and Enrichment in Lung and Esophageal Cancers
Author Information
Author(s): Nguyen Giang Huong, Murph Mandi M., Chang Joe Y.
Primary Institution: Balliol College, University of Oxford; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia; Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center
Hypothesis
The presence of cancer stem cells (CSCs) affects treatment efficacy and patient prognosis in lung and esophageal cancers.
Conclusion
Cancer stem cells contribute to radioresistance in lung and esophageal cancers, complicating treatment outcomes.
Supporting Evidence
- CSCs are more resistant to radiation therapy than non-stem cells.
- Radiation can enrich the fraction of cells expressing CSC markers.
- CD133+ lung cancer cells show increased tumorigenicity and chemoresistance.
- CSCs have high free radical scavenger levels and efficient DNA repair machinery.
- Fractionated irradiation may induce CSC differentiation.
Takeaway
Some cancer cells act like stem cells and can survive treatments, making it harder to get rid of the cancer completely.
Methodology
The review discusses various studies on cancer stem cells, their markers, and their role in radioresistance.
Limitations
The review highlights the need for more research on specific cancer stem cell markers in lung and esophageal cancers.
Digital Object Identifier (DOI)
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