2,2-Dimethyl-N-(2-methylphenylsulfonyl)propanamide
2011
Study of a Sulfonamide Compound's Crystal Structure
publication
Evidence: moderate
Author Information
Author(s): Shakuntala K., Foro Sabine, Gowda B. Thimme
Primary Institution: Mangalore University
Hypothesis
The nature and position of substituents significantly affect the crystal structures of N-(aryl)sulfonamides.
Conclusion
The crystal structure of the compound shows specific hydrogen bonding patterns that link molecules into dimers.
Supporting Evidence
- The amide hydrogen is positioned syn to the ortho-methyl group in the benzene ring.
- The crystal structure features inversion-related dimers linked by pairs of N—H⋯O hydrogen bonds.
- The C—S—N—C torsion angle is measured at -65.39°.
Takeaway
This study looks at how different parts of a sulfonamide molecule affect its crystal shape, showing that they can stick together in specific ways.
Methodology
The compound was synthesized and its crystal structure was analyzed using X-ray diffraction.
Digital Object Identifier (DOI)
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