Sleep Quality in Cystic Fibrosis: Differences Between Men and Women
Author Information
Author(s): Dietz-Terjung Sarah, Straßburg Svenja, Schulte Tim, Dietz Paul, Weinreich Gerhard, Taube Christian, Schöbel Christoph, Welsner Matthias, Sutharsan Sivagurunathan
Primary Institution: University Hospital Essen—Ruhrlandklinik, University of Duisburg-Essen
Hypothesis
What are the sex-specific differences in sleep profiles and responses to elexacaftor/tezacaftor/ivacaftor therapy in people with cystic fibrosis?
Conclusion
Women with cystic fibrosis experience poorer sleep quality and should be managed differently than men regarding their sleep.
Supporting Evidence
- Women with cystic fibrosis had a higher arousal index and daytime sleepiness than men.
- After 6 months of therapy, women showed more respiratory-effort-related arousals than men.
- Both men and women with cystic fibrosis had fewer respiratory events during sleep compared to lung-healthy controls.
Takeaway
This study found that women with cystic fibrosis have worse sleep than men, and their treatment needs to be different.
Methodology
The study compared polysomnography data of adults with cystic fibrosis before and after 6 months of therapy, alongside a matched control group.
Limitations
The sample size was small, and not all participants completed follow-up assessments.
Participant Demographics
Participants included 12 women and 16 men with cystic fibrosis, aged over 18 years.
Statistical Information
P-Value
p = 0.004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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