The Influence of the Host on Gastric Cancer
Author Information
Author(s): C.W. Janssen Jr, R.T. Lie, C.-F. Bassoe, H. Maartmann-Moe, R. Matres
Primary Institution: The Gade Institute, University of Bergen
Hypothesis
Is the altered immune state found in many cancer patients a consequence of malignancy or rather a state that influences the growth and spread of cancer?
Conclusion
The preoperative immune state significantly influences whether gastric cancer will recur and how soon.
Supporting Evidence
- The preoperative concentrations of C1-INH and C4 were higher in patients with recurrence than in 5-year survivors.
- 76% of patients were correctly classified as to recurrence based on preoperative immune data.
- The preoperative C1-INH concentration had a highly significant effect on time to recurrence of cancer.
Takeaway
Doctors studied blood from patients with stomach cancer to see how their immune system affects cancer recurrence. They found that certain immune markers can help predict if the cancer will come back.
Methodology
Patients with gastric carcinoma were followed for 5 years, with preoperative serum samples analyzed for immunoglobulins and complement components.
Limitations
The study excluded patients with other diseases or a history of another malignant disease within 5 years before surgery.
Participant Demographics
Mean age was 67.1 years, 38.3% were women.
Statistical Information
P-Value
0.0007
Statistical Significance
p<0.0005
Want to read the original?
Access the complete publication on the publisher's website