Fatty Acids and Gastric Ulceration
Author Information
Author(s): Pagkalos Vasileios A, Moschandreas Joanna, Kiriakakis Michael, Roussomoustakaki Maria, Kafatos Anthony, Kouroumalis Elias
Primary Institution: University Hospital of Heraklion, Crete, Greece
Hypothesis
Is there a relation between the fatty acid composition of subcutaneous adipose tissue and gastric mucosa with gastric ulceration?
Conclusion
Certain minor MUFAs and PUFAs of the gastric mucosa appear to be present in higher proportions in ulcer negative patients, suggesting a possible protective role against gastric ulceration.
Supporting Evidence
- 31% of participants had gastric ulceration.
- Certain fatty acids were found in higher levels in ulcer negative patients.
- Statistically significant differences were found for specific fatty acids between groups.
Takeaway
This study looked at the fats in people's bodies to see if they relate to stomach ulcers. It found that some fats might help protect against ulcers.
Methodology
The study involved 52 adult outpatients undergoing endoscopy, with adipose tissue samples taken from the abdomen and buttock, and gastric tissue samples from a subset of 30 subjects.
Potential Biases
Potential bias due to the exclusion of patients on certain medications and the small number of subjects with gastric ulceration.
Limitations
The study's findings are based on a relatively small sample size and may not be generalizable.
Participant Demographics
Participants were adult outpatients aged 21 to 89 years, with a mean age of 60 years.
Statistical Information
P-Value
0.003
Confidence Interval
95% CI for various fatty acids reported
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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