Alpha-Tomatine Induces Apoptosis and Inhibits Nuclear Factor-Kappa B Activation on Human Prostatic Adenocarcinoma PC-3 Cells
2011
Alpha-Tomatine and Prostate Cancer Cells
publication
Evidence: moderate
Author Information
Author(s): Lee Sui-Ting, Wong Pooi-Fong, Cheah Shiau-Chuen, Mustafa Mohd Rais
Primary Institution: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Hypothesis
This study investigates the chemopreventive potential of α-tomatine on androgen-independent human prostatic adenocarcinoma PC-3 cells.
Conclusion
α-tomatine induces apoptosis and inhibits NF-κB activation on prostate cancer cells.
Supporting Evidence
- α-tomatine showed a concentration-dependent inhibition of PC-3 cell growth.
- The EC50 value for α-tomatine on PC-3 cells was 1.67±0.3 µM.
- Treatment with α-tomatine resulted in increased early and late apoptotic cells.
- α-tomatine inhibited NF-κB nuclear translocation in PC-3 cells.
Takeaway
α-tomatine, a compound found in tomatoes, can help kill prostate cancer cells and stop them from growing.
Methodology
The study used various assays including MTT, flow cytometry, and high content screening to assess the effects of α-tomatine on PC-3 cells.
Statistical Information
P-Value
1.67±0.3 µM
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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