Apelin Reduces Osteoblastic Differentiation in Vascular Smooth Muscle Cells
Author Information
Author(s): Shan Peng-Fei, Lu Ying, Cui Rong-Rong, Jiang Yi, Yuan Ling-Qing, Liao Er-Yuan
Primary Institution: The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China
Hypothesis
The apelin-APJ signaling system is involved in the regulation of the osteoblastic differentiation of vascular smooth muscle cells (VSMCs).
Conclusion
Apelin inhibits the osteoblastic differentiation of vascular smooth muscle cells through the APJ/ERK and APJ/PI3-K/Akt signaling pathways.
Supporting Evidence
- Apelin treatment significantly inhibited alkaline phosphatase (ALP) activity in a dose-dependent manner.
- Apelin decreased osteocalcin secretion in cultured CVSMCs.
- Apelin reduced the formation of mineralized nodules in CVSMCs.
Takeaway
Apelin is a substance that helps keep blood vessels healthy by stopping certain cells from turning into bone-like cells, which can cause problems in the heart.
Methodology
The study used calcifying vascular smooth muscle cells (CVMSCs) to investigate the effects of apelin on osteoblastic differentiation and the involved signaling pathways.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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