Impact of C-Reactive Protein on Weight Loss After Bariatric Surgery
Author Information
Author(s): Saarinen Ilmari, Strandberg Marjatta, Hurme Saija, Grönroos Sofia, Juuti Anne, Helmiö Mika, Salminen Paulina
Primary Institution: University of Turku, Turku, Finland
Hypothesis
This study aims to evaluate chronic inflammation in patients with obesity using hs-CRP, and its association with long-term weight loss outcomes after laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB).
Conclusion
Metabolic bariatric surgery decreases hs-CRP at long-term follow-up with weight loss as the driving force.
Supporting Evidence
- MBS decreases hs-CRP levels at long-term follow-up.
- Higher hs-CRP correlated with higher BMI at baseline and at 10 years.
- A greater percentage total weight loss correlated with lower hs-CRP levels at 10 years.
Takeaway
This study found that surgery to help with obesity can lower inflammation levels in the body over a long time, especially if people lose weight.
Methodology
The study used long-term follow-up data from the SLEEVEPASS randomized clinical trial, measuring hs-CRP at multiple time points post-surgery.
Potential Biases
The higher baseline hs-CRP in the LSG group may be influenced by the small sample size.
Limitations
The small number of patients with available hs-CRP values at baseline and follow-up time points limits the generalizability of the results.
Participant Demographics
The study included 59 patients with severe obesity, with a mean age of 47 years, and a mix of genders.
Statistical Information
P-Value
p=0.003
Confidence Interval
95% CI 0.87–1.49
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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