E3 UBIQUITIN LIGASE2 SIAH2 MAY REGULATE AGE-ASSOCIATED LIPID TURNOVER IN ADIPOSE TISSUE MACROPHAGES
2024
Siah2 and Lipid Turnover in Aging Macrophages
publication
Author Information
Author(s): Ghosh Bhaswati
Primary Institution: Pennington Biomedical Research Center
Hypothesis
Aging downregulates proteasomal activity in adipose tissue macrophages (ATMs) resulting in dysfunctional lipid metabolism.
Conclusion
Siah2 functions as a critical lipid sensor in ATMs, and aging may lead to decreased Siah2 activity, resulting in reduced lipid turnover.
Supporting Evidence
- SKM-ATMs accumulate more and larger lipid droplets than WT-ATMs.
- Siah2KO in ATMs suppresses lysosomal delivery of lipid droplets.
- SKM-BMDMs are pro-inflammatory and show decreased oxygen consumption rate.
Takeaway
As we get older, a protein called Siah2 in certain immune cells helps manage fat. If it doesn't work well, it can lead to more fat buildup.
Methodology
Generated a macrophage-specific Siah2 knockout mouse model and co-cultured primary bone marrow-derived macrophages with adipose tissue.
Digital Object Identifier (DOI)
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