Pediatric Selective IgM Immunodeficiency
Author Information
Author(s): Marc F. Goldstein, Alex L. Goldstein, Eliot H. Dunsky, Donald J. Dvorin, George A. Belecanech, Kfir Shamir
Primary Institution: The Asthma Center, Allergic Disease Associates, PC
Hypothesis
What are the features and prevalence of pediatric Selective IgM immunodeficiency (SIgMID)?
Conclusion
The prevalence of SIgMID in our pediatric population was found to be 0.03%, with respiratory infections being the most common comorbid condition.
Supporting Evidence
- Forty-nine reported cases of SIgMID presented with respiratory infections (77.6%).
- Mean serum IgM level was 16.5 ± 13.8 mg/dL.
- Two patients were identified with SIgMID among 6300 active pediatric patients (0.03%).
- None of the patients developed lymphoproliferative disease nor evolved into panhypogammaglobulinemia.
Takeaway
Some kids have a rare condition called SIgMID that makes them get sick more often, especially with lung infections, but it's not usually very serious.
Methodology
A retrospective medical record review of 20,000 patients, focusing on those diagnosed with SIgMID and analyzing their clinical features.
Limitations
Asymptomatic patients may have been missed since only symptomatic patients were screened for immunodeficiency.
Participant Demographics
The pediatric population included 2 Caucasian males identified with SIgMID among 6300 active pediatric patients.
Digital Object Identifier (DOI)
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