Methods to test for association between a disease and a multi-allelic marker applied to a candidate region
2005

Association between Kofendrerd Personality Disorder and Multi-Allelic Markers

Sample size: 150 publication Evidence: moderate

Author Information

Author(s): Rachid El Galta, Li Hsu, Jeanine J Houwing-Duistermaat

Primary Institution: Leiden University Medical Centre

Hypothesis

Is there an association between Kofendrerd Personality Disorder and multi-allelic markers in a candidate region?

Conclusion

Marker D03S0127 showed significant association with Kofendrerd Personality Disorder.

Supporting Evidence

  • Marker D03S0127 was found to be significantly associated with Kofendrerd Personality Disorder.
  • Both score U and Pearson's χ2 tests yielded similar p-values for the association.
  • Terwilliger's LR test yielded a larger p-value compared to the other tests.

Takeaway

The study looked at a disease and some genetic markers to see if they are related, and found that one specific marker is linked to the disease.

Methodology

The study used Pearson's χ2, score test, and Terwilliger's LR test on case-control data.

Limitations

The study may have limitations due to the complexity of the genetic markers and the need for further simulation studies.

Participant Demographics

100 cases and 50 controls were analyzed.

Statistical Information

P-Value

p = 0.008

Statistical Significance

p<0.01

Digital Object Identifier (DOI)

10.1186/1471-2156-6-S1-S101

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