Activin B Promotes Epithelial Wound Healing In Vivo through RhoA-JNK Signaling Pathway
2011
Activin B Promotes Epithelial Wound Healing In Vivo through RhoA-JNK Signaling Pathway
Sample size: 44
publication
10 minutes
Evidence: high
Author Information
Author(s): Zhang Min, Liu Nu-Yun, Wang Xue-Er, Chen Ying-Hua, Li Qing-Lin, Lu Kang-Rong, Sun Li, Jia Qin, Zhang Lu, Zhang Lin
Primary Institution: Southern Medical University, Guangzhou, China
Hypothesis
The study investigates the mechanism by which activin B induces epithelial wound healing in mice.
Conclusion
Activin B promotes epithelial wound closure in vivo through the RhoA-Rock-JNK-cJun signaling pathway.
Supporting Evidence
- Activin B significantly increased the number of keratinocytes at the wound edge.
- RhoA activation enhanced JNK activity, which is crucial for wound healing.
- JNK inhibition suppressed the wound healing process induced by activin B.
Takeaway
Activin B helps heal wounds by making skin cells grow and move to cover the injury.
Methodology
The study used recombinant lentiviral plasmids to infect wounded mice and monitored the wound healing process with various assays.
Participant Demographics
Male and female specific pathogen-free Kunming (KM) mice aged 10-12 weeks.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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