Outcomes in Adenoid Cystic Carcinoma: A 14-Year Analysis
Author Information
Author(s): Muacevic Alexander, Adler John R, Bin Sumaida Abdulrahman, Shanbhag Nandan M, AlKaabi Khalifa, Hasnain Syed Mansoor, Balaraj Khalid
Primary Institution: Tawam Hospital, Al Ain, ARE
Hypothesis
This study aims to evaluate the demographic patterns, clinical presentations, outcomes, and survival trends of patients with adenoid cystic carcinoma (ACC).
Conclusion
ACC predominantly affects middle-aged individuals and is associated with high rates of local recurrence and distant metastases, especially to the lungs.
Supporting Evidence
- Local recurrence was present in 42.9% of patients.
- Distant metastases were observed in 42.9% of patients, primarily to the lungs.
- Overall survival was 85.7% over a mean follow-up of 4.3 years.
- Smoking was associated with poorer survival trends, though not statistically significant.
Takeaway
Adenoid cystic carcinoma is a rare cancer that often comes back after treatment and can spread to the lungs, mostly affecting middle-aged men.
Methodology
A retrospective analysis of 14 patients diagnosed with ACC from 2010 to 2024 at a tertiary cancer center in the UAE, analyzing demographics, symptoms, outcomes, and survival trends.
Potential Biases
The retrospective nature of the study introduces potential biases, including incomplete data on treatments and outcomes.
Limitations
The small sample size (n=14) is a primary limitation, affecting statistical power and generalizability.
Participant Demographics
The cohort consisted of 14 patients, predominantly male (64.3%) with a mean age of 38.9 years.
Statistical Information
P-Value
0.083
Confidence Interval
95% CI 0.002-9.483
Statistical Significance
p=0.083
Digital Object Identifier (DOI)
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