Link Between PTPN22 Gene and Psoriatic Arthritis
Author Information
Author(s): Kristina Juneblad, Martin Johansson, Solbritt Rantapää-Dahlqvist, Gerd-Marie Alenius
Primary Institution: Department of Public Health and Clinical Medicine, Rheumatology, University Hospital, Umeå, Sweden
Hypothesis
Is the PTPN22 +1858 C/T polymorphism associated with psoriatic arthritis?
Conclusion
The +1858T allele of the PTPN22 gene is associated with psoriatic arthritis and may indicate a more aggressive disease phenotype.
Supporting Evidence
- Carriers of the PTPN22 +1858T allele had significantly more deformed joints compared to non-carriers.
- The study included a large control group from the same geographic area as the patients.
- The association was stronger when excluding RF and ACPA sero-positive patients.
Takeaway
This study found that a specific gene variant is linked to a type of arthritis, suggesting that people with this variant might have a more severe form of the disease.
Methodology
A case-control study comparing 291 patients with psoriatic arthritis to 725 controls, examining the PTPN22 +1858 C/T SNP.
Potential Biases
Potential misdiagnosis of patients could affect results.
Limitations
The sample size may not allow for proper stratification of data, particularly for sub-groups like RF and ACPA sero-positive subjects.
Participant Demographics
291 patients (145 male, 146 female) with a mean age of 52.2 years.
Statistical Information
P-Value
0.010
Confidence Interval
1.10 to 2.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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