Factors Affecting Selenium Levels in Healthy Adults
Author Information
Author(s): Gerald F Combs Jr, Jennifer C Watts, Matthew I Jackson, LuAnn K Johnson, Huawei Zeng, Angela J Scheett, Eric O Uthus, Lutz Schomburg, Antonia Hoeg, Carolin S Hoefig, Cindy D Davis, John A Milner
Primary Institution: Grand Forks Human Nutrition Research Center, USDA-ARS, Grand Forks, ND, USA
Hypothesis
What factors influence selenium status in healthy, non-deficient individuals?
Conclusion
Genetic factors, dietary intake, and body mass index significantly affect selenium biomarkers in healthy adults.
Supporting Evidence
- Plasma selenium levels were found to be 142.0 ± 23.5 ng/ml.
- Women had higher urinary selenium levels than men.
- Genetic variations in GPX1 and SEPP1 were linked to differences in selenium levels.
Takeaway
This study looked at how different things like genes and diet affect selenium levels in healthy people. It found that these factors can change how much selenium is in their bodies.
Methodology
The study evaluated multiple biomarkers of selenium status in a cohort of healthy adults, analyzing their relationship with dietary intake and genetic factors.
Potential Biases
Potential bias due to the self-selection of volunteers and the exclusion of individuals with certain health conditions.
Limitations
The study's reliance on self-reported dietary intake may introduce inaccuracies in estimating selenium consumption.
Participant Demographics
The cohort consisted of 106 men and 155 women, with an average age of 49.6 years and a BMI of 27.4.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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